TGF-beta (Transforming Growth Factor beta) (clone 1D11.16.8 ), anti-human, mouse, drosophila, bovine, dog, hamster, primate

Background:
This MAb recognizes TGF beta 1, 2 and 3. Three TGFĪ �s have been identified in mammals. TGFĪ �1, TGFĪ �2 and TGFĪ �3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFĪ � requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFĪ �3 protein has approximately 80% identity to the mature region of both TGFĪ �1 and TGFĪ �2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFĪ �ā€™s inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Ā

Other Names:
Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB

Gene Name: TGFB1 (HGNC:11766)
Gene ID: 7040
Primary Accession: P01137
Other Accession: 7040 (beta1), 7042 (beta2), 7043 (beta3), 645227,P10600 (beta2),P61812 (beta3)