TGF beta1 (clone 4F9C10,1B11B7), anti-human
€362.00
In stock
SKU
252657
Protein Family: Transporters, Chaperones and Folding Catalysts, Cytokines, CAM Ligands
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Immune System, Cell Growth and Death, Development and Behavior, Cancers, Infectious Diseases
Description:
TGF-beta 1 (Transforming growth factor beta-1) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. The inactive form consists of a TGF-beta 1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The active form is a homodimer of mature, disulfide-linked TGF-beta 1. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Defects in TGF-beta 1 are the cause of Camurati-Engelmann disease (CE), also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
Alternate Names: Transforming growth factor beta-1, TGF-beta-1, TGFB1, TGFB, Latency-associated peptide, LAP
Application Notes: WB: 1:500-1:2000
Accession No.: P01137
Antigen: Purified recombinant fragment of TGFbeta1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction, Signal Transduction, Immune System, Cell Growth and Death, Development and Behavior, Cancers, Infectious Diseases
Description:
TGF-beta 1 (Transforming growth factor beta-1) is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. The inactive form consists of a TGF-beta 1 homodimer non-covalently linked to a latency-associated peptide (LAP) homodimer. The active form is a homodimer of mature, disulfide-linked TGF-beta 1. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Defects in TGF-beta 1 are the cause of Camurati-Engelmann disease (CE), also known as progressive diaphyseal dysplasia 1 (DPD1). CE is an autosomal dominant disorder characterized by hyperostosis and sclerosis of the diaphyses of long bones. The disease typically presents in early childhood with pain, muscular weakness and waddling gait, and in some cases other features such as exophthalmos, facial paralysis, hearing difficulties and loss of vision.
Alternate Names: Transforming growth factor beta-1, TGF-beta-1, TGFB1, TGFB, Latency-associated peptide, LAP
Application Notes: WB: 1:500-1:2000
Accession No.: P01137
Antigen: Purified recombinant fragment of TGFbeta1 expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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