TGFβ RII (phospho-S225/250) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64035
Background:
A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor (TGFβ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGFβ RII (TGF-β receptor type-2), also known as TGFBR2, is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain and is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. For signaling growth inhibition and early gene responses, TGFβ RII requires both its kinase activity and association with a TGFβ- binding protein, designated the type I receptor. TGFβ RII exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 3.
Alternative Name:
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Application Dilution: WB: 1:500~1:1000
Specificity: p-TGFBR2 (S225/250) polyclonal antibody detects endogenous levels of human and rat TGFBR2 protein only when phosphorylated at Ser225. This antibody also recognizes mouse TGFBR2 protein only when phosphorylated at Ser250.
Immunogen:
A synthetic peptide corresponding to residues in Human TGFBR2 around the phosphorylation site of ser225/250.
MW: ~ 65 kDa
Swis Prot.: P37173
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
A total of three members of the TGFβ family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFβs mediate their activity by high affinity binding to the type II receptor (TGFβ RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. TGFβ RII (TGF-β receptor type-2), also known as TGFBR2, is a 567 amino acid single-pass type I membrane protein that contains one protein kinase domain and is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. For signaling growth inhibition and early gene responses, TGFβ RII requires both its kinase activity and association with a TGFβ- binding protein, designated the type I receptor. TGFβ RII exists as two alternatively spliced isoforms that are encoded by a gene that maps to human chromosome 3.
Alternative Name:
TGF-beta receptor type-2, TGFR-2, TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TGF-beta receptor type II, TbetaR-II, TGFBR2
Application Dilution: WB: 1:500~1:1000
Specificity: p-TGFBR2 (S225/250) polyclonal antibody detects endogenous levels of human and rat TGFBR2 protein only when phosphorylated at Ser225. This antibody also recognizes mouse TGFBR2 protein only when phosphorylated at Ser250.
Immunogen:
A synthetic peptide corresponding to residues in Human TGFBR2 around the phosphorylation site of ser225/250.
MW: ~ 65 kDa
Swis Prot.: P37173
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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