TGFB2 monoclonal, anti-human
€0.00
In stock
SKU
AC-AM1893B
Catalog Number: AC-AM1893B
Size: 80 µl, 400 µl
Isotype: mouse IgG1,K
Clone Name: 220ct16.4.3.1
Applications: WB, IF, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: mouse IgG1,K
Clone Name: 220ct16.4.3.1
Applications: WB, IF, IHC-P
Datasheet
Request Information
Background:
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2
Target/Specificity:
This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Antigen Type: Recombinant Protein
Gene Name: TGFB2
Gene ID: 7042
Primary Accession: P61812
NCBI Accession: NP_001129071.1;NP_003229.1
Other Accession: NP_001129071.1;NP_003229.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Other Names:
Transforming growth factor beta-2, TGF-beta-2, BSC-1 cell growth inhibitor, Cetermin, Glioblastoma-derived T-cell suppressor factor, G-TSF, Polyergin, Latency-associated peptide, LAP, TGFB2
Target/Specificity:
This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Antigen Type: Recombinant Protein
Gene Name: TGFB2
Gene ID: 7042
Primary Accession: P61812
NCBI Accession: NP_001129071.1;NP_003229.1
Other Accession: NP_001129071.1;NP_003229.1
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
| Is Featured? | No |
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