TGIF1 Antibody (Center A160) Blocking peptide
€363.00
In stock
SKU
AC-BP12062c
Background:
The protein encoded by this gene is a member of thethree-amino acid loop extension (TALE) superclass of atypicalhomeodomains. TALE homeobox proteins are highly conservedtranscription regulators. This particular homeodomain binds to apreviously characterized retinoid X receptor responsive elementfrom the cellular retinol-binding protein II promoter. In additionto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphatranscription activation of the retinoic acid responsive element,the protein is an active transcriptional co-repressor of SMAD2 andmay participate in the transmission of nuclear signals duringdevelopment and in the adult. Mutations in this gene are associatedwith holoprosencephaly type 4, which is a structural anomaly of thebrain. Alternative splicing has been observed at this locus andeight variants, encoding four distinct isoforms, are described.
Other Names:
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Gene Name: TGIF1
Gene ID: 7050
Primary Accession: Q15583
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of thethree-amino acid loop extension (TALE) superclass of atypicalhomeodomains. TALE homeobox proteins are highly conservedtranscription regulators. This particular homeodomain binds to apreviously characterized retinoid X receptor responsive elementfrom the cellular retinol-binding protein II promoter. In additionto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphatranscription activation of the retinoic acid responsive element,the protein is an active transcriptional co-repressor of SMAD2 andmay participate in the transmission of nuclear signals duringdevelopment and in the adult. Mutations in this gene are associatedwith holoprosencephaly type 4, which is a structural anomaly of thebrain. Alternative splicing has been observed at this locus andeight variants, encoding four distinct isoforms, are described.
Other Names:
Homeobox protein TGIF1, 5'-TG-3'-interacting factor 1, TGIF1, TGIF
Gene Name: TGIF1
Gene ID: 7050
Primary Accession: Q15583
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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