TGS1 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS70955
Background:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation
Alternative Name:
PIMT, PIPMT, TGS1, HCA137, NCOA6IP, PIMT
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: TGS1 polyclonal antibody detects endogenous levels of TGS1 protein.
Immunogen:
Recombinant protein of human TGS1.
MW: ~ 97 kDa
Swis Prot.: Q96RS0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m7G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation
Alternative Name:
PIMT, PIPMT, TGS1, HCA137, NCOA6IP, PIMT
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: TGS1 polyclonal antibody detects endogenous levels of TGS1 protein.
Immunogen:
Recombinant protein of human TGS1.
MW: ~ 97 kDa
Swis Prot.: Q96RS0
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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