Thymidylate Synthase (5-FU Resistance Marker) (clone SPM453 ), anti-human

Background:
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Other Names:
Thymidylate synthase, TS, TSase, 2.1.1.45, TYMS, TS

Gene Name: TYMS (HGNC:12441)
Gene ID: 7298
Primary Accession: P04818
Other Accession: 7298, 369762