Thymidylate Synthase [clone TS106+TMS715], anti-human

Description: TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.Localization: cytoplasm, nucleusDilution: 50-200Positive Control: colorectal, gastric, head & neck, breast caHIER: citrate pH6.0 or EDTA pH8.0Status: RUO