Thyroid Hormone Receptor alpha1/alpha2 (clone 2103), anti-human, mouse, rat, dog
€510.00
In stock
SKU
253228
Protein Family: Transcription Factors; Receptors and Channels
Pathway and Disease: Transcription
Description:
Thyroid hormones are essential for development of the central nervous system. Deficits in these hormones during development affect cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TRb1 and TRb2. TRa1, TRb1 and TRb2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain.
Alternate Names: Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha
Application Notes: E: 1:500-1:1,000; WB: 1:1,000
Accession No.: P10827
Antigen: KLH-conjugated peptide encompassing a sequence within the N-term region of human thyroid hormone receptor, a1/a2-isotype.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Transcription
Description:
Thyroid hormones are essential for development of the central nervous system. Deficits in these hormones during development affect cognitive functions as learning and memory. Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TRb1 and TRb2. TRa1, TRb1 and TRb2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain.
Alternate Names: Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, EAR-7, c-erbA-1, c-erbA-alpha
Application Notes: E: 1:500-1:1,000; WB: 1:1,000
Accession No.: P10827
Antigen: KLH-conjugated peptide encompassing a sequence within the N-term region of human thyroid hormone receptor, a1/a2-isotype.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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