Tim3 (clone ), anti-human

Background:
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse.

Alternative Name:
HAVcr-2, TIMD-3, TIM-3, HAVCR2, TIM3, TIMD3, CD366, FLJ14428, HAVcr-2, Havcr2, HAVR2, Hepatitis A virus cellular receptor 2, Kidney injury molecule 3, KIM 3, KIM3, T cell immunoglobulin and mucin domain containing 3, T cell immunoglobulin mucin 3, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin family member 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, Tim 3, TIM-3, TIM3, TIMD-3, TIMD3,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200
IHC:1:100-1:200
FC:1:50-1:100

Specificity: Tim3 monoclonal antibody detects endogenous levels of Tim3 protein.

Immunogen:
Recombinant protein

MW: 33 kDa (Predicted band size)

Swiss-Prot: Q8TDQ0(Human)

Purification & Purity:
ProA affinity purified

Format:
Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.