TK (phospho-S13) polyclonal, anti-human
€328.00
In stock
SKU
BS4365
Background:
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.
Alternative Name:
TK1, Thymidine Kinase, TK2
Application Dilution: WB: 1:500~1:1000
Specificity: TK (phospho-S13) polyclonal antibody detects endogenous levels of Thymidine Kinase protein only when phosphorylated at Ser13.
Immunogen:
Synthetic peptide derived from human TK around the phosphorylation site of S13.
MW: ~ 25 kDa
Swis Prot.: P04183
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.
Alternative Name:
TK1, Thymidine Kinase, TK2
Application Dilution: WB: 1:500~1:1000
Specificity: TK (phospho-S13) polyclonal antibody detects endogenous levels of Thymidine Kinase protein only when phosphorylated at Ser13.
Immunogen:
Synthetic peptide derived from human TK around the phosphorylation site of S13.
MW: ~ 25 kDa
Swis Prot.: P04183
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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