TLR4 antibody (clone 1H7), anti-human
€435.00
In stock
SKU
AC-AT4256a
Catalog Number: AC-AT4256a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, E
Request Information AC-AT4256a">Request Information
Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Other Names:
Toll-like receptor 4, hToll, CD284, TLR4
Antigen Type:
Recombinant Protein
Gene Name: TLR4
Gene ID: 7099
NCBI Accession: NP_003257.1;NP_612564.1;NP_612567.1
Primary Accession: O00206
Other Accession: NM_138554
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Other Names:
Toll-like receptor 4, hToll, CD284, TLR4
Antigen Type:
Recombinant Protein
Gene Name: TLR4
Gene ID: 7099
NCBI Accession: NP_003257.1;NP_612564.1;NP_612567.1
Primary Accession: O00206
Other Accession: NM_138554
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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