TNFα-IP8 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS5965
Background:
TNFα-IP 8 (tumor necrosis factor, α-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFα-IP 8 by TNF is dependent on the activation of NFκB. TNFα-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFα-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFα-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFα-IP 8 is present as three isoforms produced by alternative splicing.
Alternative Name:
Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, MDC3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, SCC S2, SCCS2, TNF-induced protein GG2-1, TNFAIP8, TNFα IP8, TNFαIP8, TNFα-IP 8
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: TNFα-IP8 polyclonal antibody detects endogenous levels of TNFα-IP8 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 71-116 of Human TNFα-IP83.
MW: ~ 23 kDa
Swis Prot.: O95379
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
TNFα-IP 8 (tumor necrosis factor, α-induced protein 8), also known as NFκB-inducible DED-containing protein (NDED), SCC-S2 or TNF-induced protein GG2-1, is a 198 amino acid cytoplasmic protein induced by NFκB and TNF. The induction of TNFα-IP 8 by TNF is dependent on the activation of NFκB. TNFα-IP 8 negatively mediates apoptosis and may also play a role in tumor progression. TNFα-IP 8 specifically inhibits caspase-8 activity, which results in the inhibition of BID cleavage and caspase-3 activation during TNF-mediated apoptosis. TNFα-IP 8 is expressed at high levels in thymus, bone marrow, lymph node, spleen, thyroid, placenta and various tumor tissues, as well as fetal lung, liver and kidney. TNFα-IP 8 is present as three isoforms produced by alternative splicing.
Alternative Name:
Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, MDC-3.13, MDC3.13, NF-kappa-B-inducible DED-containing protein, NDED, SCC-S2, SCC S2, SCCS2, TNF-induced protein GG2-1, TNFAIP8, TNFα IP8, TNFαIP8, TNFα-IP 8
Application Dilution: WB: 1:500~1:1000, IF: 1:200
Specificity: TNFα-IP8 polyclonal antibody detects endogenous levels of TNFα-IP8 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 71-116 of Human TNFα-IP83.
MW: ~ 23 kDa
Swis Prot.: O95379
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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