TNFRSF10B (clone 2H5B8), anti-human

Background:
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.

Research Area: Signal transduction, Cardiovascular, Cancer

Synonyms: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5

Immunogen: Purified recombinant fragment of human TNFRSF10B (AA: extra 56-210) expressed in E. Coli.

Formulation: Purified antibody in PBS with 0.05% sodium azide

Storage:
4°C|-20°C for long term storage