TNFRSF11B (clone 5A11), anti-human

Protein Family: Cellular Antigens, Receptors and Channels

Pathway and Disease: Development and Behavior, Signaling Molecules and Interaction

Description:
OPG (Osteoprotegerin) is a decoy receptor for RANKL by neutralizing its function in osteoclastogenesis. OPG inhibits osteoclast activation and promotes osteoclast apoptosis in vitro. OPG is up-regulated by increasing calcium concentration and estrogens. Defects in OPG are the cause of juvenile Paget disease, which is characterized by rapid bone remodeling leading to deformities, fractures and osteopenia.

Alternate Names: Tumor necrosis factor receptor superfamily member 11B, Osteoprotegerin, Osteoclastogenesis inhibitory factor, TNFRSF11B, OCIF, OPG

Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000

Accession No.: O00300

Antigen: Purified recombinant fragment of human TNFRSF11B expressed in E. coli.

Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.