TNFRSF13C Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP14039a
Background:
B cell-activating factor (BAFF) enhances B-cell survivalin vitro and is a regulator of the peripheral B-cell population.Overexpression of Baff in mice results in mature B-cell hyperplasiaand symptoms of systemic lupus erythematosus (SLE). Also, some SLEpatients have increased levels of BAFF in serum. Therefore, it hasbeen proposed that abnormally high levels of BAFF may contribute tothe pathogenesis of autoimmune diseases by enhancing the survivalof autoreactive B cells. The protein encoded by this gene is areceptor for BAFF and is a type III transmembrane proteincontaining a single extracellular cysteine-rich domain. It isthought that this receptor is the principal receptor required forBAFF-mediated mature B-cell survival.
Other Names:
Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268, TNFRSF13C, BAFFR, BR3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14039a was selected from the N-term region of TNFRSF13C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TNFRSF13C
Gene ID: 115650
Primary Accession: Q96RJ3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
B cell-activating factor (BAFF) enhances B-cell survivalin vitro and is a regulator of the peripheral B-cell population.Overexpression of Baff in mice results in mature B-cell hyperplasiaand symptoms of systemic lupus erythematosus (SLE). Also, some SLEpatients have increased levels of BAFF in serum. Therefore, it hasbeen proposed that abnormally high levels of BAFF may contribute tothe pathogenesis of autoimmune diseases by enhancing the survivalof autoreactive B cells. The protein encoded by this gene is areceptor for BAFF and is a type III transmembrane proteincontaining a single extracellular cysteine-rich domain. It isthought that this receptor is the principal receptor required forBAFF-mediated mature B-cell survival.
Other Names:
Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268, TNFRSF13C, BAFFR, BR3
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP14039a was selected from the N-term region of TNFRSF13C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TNFRSF13C
Gene ID: 115650
Primary Accession: Q96RJ3
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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