TNFSF18 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61856
Background:
GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFκB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).
Alternative Name:
Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL
Application Dilution: WB: 1:500~1:1000
Specificity: TNFSF18 pAb detects endogenous levels of TNFSF18 protein.
Immunogen:
Synthetic peptide, corresponding Human TNFSF18.
MW: ~ 22 kDa
Swis Prot.: Q9UNG2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
GITRL (glucocorticoid-induced TNF-related ligand), a polypeptide encoded by a human umbilical endothelial cell cDNA, is a member of the TNF (tumor necrosis factor) superfamily. GITRL has a type 2 transmembrane topology that is characteristic of the TNF family. The TNF superfamilies regulate diverse biological functions, including cell proliferation, differentiation and survival. GITRL is found on vascular endothelial cells and in several peripheral tissues (small intestine, ovary, testis and kidney), where it may modulate T lymphocyte survival. The GITR receptor recognizes GITRL and the two interact to regulate NFκB activation. The ligand-receptor pair of GITRL-GITR protects cells against AICD (activation-induced cell death).
Alternative Name:
Tumor necrosis factor ligand superfamily member 18, Activation-inducible TNF-related ligand, AITRL, Glucocorticoid-induced TNF-related ligand, hGITRL
Application Dilution: WB: 1:500~1:1000
Specificity: TNFSF18 pAb detects endogenous levels of TNFSF18 protein.
Immunogen:
Synthetic peptide, corresponding Human TNFSF18.
MW: ~ 22 kDa
Swis Prot.: Q9UNG2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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