TNK1 (clone 1B5G3;3F11H6), anti-human
€421.00
In stock
SKU
252782
Protein Family: Enzymes, Protein Kinases
Pathway and Disease: Cancers
Description:
TNK1 (Tyrosine kinase, non-receptor, 1) is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Alternate Names: Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1
Application Notes: WB: 1:500-1:2000
Accession No.: Q13470
Antigen: Purified recombinant fragment of TNK1(aa451-560) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers
Description:
TNK1 (Tyrosine kinase, non-receptor, 1) is a nonreceptor tyrosine kinase (NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Alternate Names: Non-receptor tyrosine-protein kinase TNK1, CD38 negative kinase 1, TNK1
Application Notes: WB: 1:500-1:2000
Accession No.: Q13470
Antigen: Purified recombinant fragment of TNK1(aa451-560) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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