TNK1 (clone 1B5G3), anti-human
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In stock
SKU
BT-MCA2822
Catalog Number: BT-MCA2822
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s):
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s):
Datasheet
Request Information
Background:
TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Research Area: Signal transduction
Synonyms: MGC46193, TNK1
Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.
Research Area: Signal transduction
Synonyms: MGC46193, TNK1
Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
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