TNK2 (phospho-Y284) polyclonal, anti-human

Background:
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Synonyms: ACK, ACK-1, ACK1, p21cdc42Hs

Cellular Location: Cell junction Cell membrane Cytoplasmic side Cytoplasmic vesicle Cytoplasmic vesicle membrane Endosome Membrane Nucleus Peripheral membrane protein adherens junction clathrin-coated pit clathrin-coated vesicle

Immunogen:
A phospho specific peptide corresponding to residues surrounding Y284 of human TNK2

Gene Symbol: Phospho-TNK2-Y284

Gene ID: 10188

Swiss prot: Q07912

Calculated MW: 115kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.