TNNT3 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP17019b
Background:
The binding of Ca(2+) to the trimeric troponin complexinitiates the process of muscle contraction. Increased Ca(2+)concentrations produce a conformational change in the troponincomplex that is transmitted to tropomyosin dimers situated alongactin filaments. The altered conformation permits increasedinteraction between a myosin head and an actin filament which,ultimately, produces a muscle contraction. The troponin complex hasprotein subunits C, I, and T. Subunit C binds Ca(2+) and subunit Ibinds to actin and inhibits actin-myosin interaction. Subunit Tbinds the troponin complex to the tropomyosin complex and is alsorequired for Ca(2+)-mediated activation of actomyosin ATPaseactivity. There are 3 different troponin T genes that encodetissue-specific isoforms of subunit T for fast skeletal-, slowskeletal-, and cardiac-muscle. This gene encodes fast skeletaltroponin T protein; also known as troponin T type 3. Alternativesplicing results in multiple transcript variants encodingadditional distinct troponin T type 3 isoforms. A developmentallyregulated switch between fetal/neonatal and adult troponin T type 3isoforms occurs. Additional splice variants have been described buttheir biological validity has not been established. Mutations inthis gene may cause distal arthrogryposis multiplex congenita type2B (DA2B).
Other Names:
Troponin T, fast skeletal muscle, TnTf, Beta-TnTF, Fast skeletal muscle troponin T, fTnT, TNNT3
Gene Name: TNNT3
Gene ID: 7140
Primary Accession: P45378
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The binding of Ca(2+) to the trimeric troponin complexinitiates the process of muscle contraction. Increased Ca(2+)concentrations produce a conformational change in the troponincomplex that is transmitted to tropomyosin dimers situated alongactin filaments. The altered conformation permits increasedinteraction between a myosin head and an actin filament which,ultimately, produces a muscle contraction. The troponin complex hasprotein subunits C, I, and T. Subunit C binds Ca(2+) and subunit Ibinds to actin and inhibits actin-myosin interaction. Subunit Tbinds the troponin complex to the tropomyosin complex and is alsorequired for Ca(2+)-mediated activation of actomyosin ATPaseactivity. There are 3 different troponin T genes that encodetissue-specific isoforms of subunit T for fast skeletal-, slowskeletal-, and cardiac-muscle. This gene encodes fast skeletaltroponin T protein; also known as troponin T type 3. Alternativesplicing results in multiple transcript variants encodingadditional distinct troponin T type 3 isoforms. A developmentallyregulated switch between fetal/neonatal and adult troponin T type 3isoforms occurs. Additional splice variants have been described buttheir biological validity has not been established. Mutations inthis gene may cause distal arthrogryposis multiplex congenita type2B (DA2B).
Other Names:
Troponin T, fast skeletal muscle, TnTf, Beta-TnTF, Fast skeletal muscle troponin T, fTnT, TNNT3
Gene Name: TNNT3
Gene ID: 7140
Primary Accession: P45378
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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