Toll-like Receptor 3 (clone 2F10-B8-G9), anti-transfected

Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Synonyms: CD283, IIAE2

Cellular Location: Early endosome Endoplasmic reticulum membrane Endosome membrane Single-pass type I membrane protein

Immunogen:
Purified recombinant human Toll-Like Receptor 3 protein fragments expressed in E.coli.

Gene Symbol: Toll-like Receptor 3

Gene ID: 7098

Swiss prot: O15455

Calculated MW: According to the fused protein

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.