Toll-like Receptor 7 (clone 3F11-2C9-D8), anti-transfected

Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: TLR7-like

Cellular Location: Cytoplasmic vesicle Endoplasmic reticulum membrane Endosome Lysosome Single-pass type I membrane protein phagosome

Immunogen:
Purified recombinant human Toll-like Receptor protein fragments expressed in E.coli.

Gene Symbol: Toll-like Receptor 7

Gene ID: 51284

Swiss prot: Q9NYK1

Calculated MW: According to the fused protein

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.