TOLLIP Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1521a
Background:
Toll-interacting protein (Tollip) was initially identified as an important constituent of the IL-1R signaling pathway. Recently it was showed that this adapter protein is also involved in TLR2 and TLR4 signaling pathways. Tollip coimmunoprecipitates with TLR2 and TLR4 and overexpression of Tollip was shown to inhibit NF-kB activation in response to TLR2 and TLR4 signaling. Human TOLLIP protein is 274-amino acid, which is 97% identical to the mouse sequence. Structurally, Tollip contains a type II C2 motif. Immunoblot analysis showed expression of a 30-kD protein in numerous tissues and cell lines. Functionally, Tollip inhibits cell activation by microbial products, recruits IRAK1 to the IL-1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. Since the inhibition by Tollip is mediated through its ability to suppress the activity of IRAK, Tollip may act as moderator of the inflammatory response following TLR activation.
Other Names:
Toll-interacting protein, TOLLIP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1521a was selected from the N-term region of human TOLLIP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TOLLIP
Gene ID: 54472
Primary Accession: Q9H0E2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Toll-interacting protein (Tollip) was initially identified as an important constituent of the IL-1R signaling pathway. Recently it was showed that this adapter protein is also involved in TLR2 and TLR4 signaling pathways. Tollip coimmunoprecipitates with TLR2 and TLR4 and overexpression of Tollip was shown to inhibit NF-kB activation in response to TLR2 and TLR4 signaling. Human TOLLIP protein is 274-amino acid, which is 97% identical to the mouse sequence. Structurally, Tollip contains a type II C2 motif. Immunoblot analysis showed expression of a 30-kD protein in numerous tissues and cell lines. Functionally, Tollip inhibits cell activation by microbial products, recruits IRAK1 to the IL-1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. Since the inhibition by Tollip is mediated through its ability to suppress the activity of IRAK, Tollip may act as moderator of the inflammatory response following TLR activation.
Other Names:
Toll-interacting protein, TOLLIP
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1521a was selected from the N-term region of human TOLLIP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TOLLIP
Gene ID: 54472
Primary Accession: Q9H0E2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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