TOP2A monoclonal, anti-human

Background:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Other Names:
DNA topoisomerase 2-alpha, DNA topoisomerase II, alpha isozyme, TOP2A, TOP2

Target/Specificity:
Purified His-tagged TOP2A protein(Fragment) was used to produced this monoclonal antibody.

Antigen Type: Recombinant Protein

Gene Name: TOP2A
Gene ID: 7153
Primary Accession: P11388
NCBI Accession: NP_001058.2
Other Accession: NP_001058.2
Format: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.