TOP2B Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP12087b
Background:
This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This nuclear enzyme is involved in processes such aschromosome condensation, chromatid separation, and the relief oftorsional stress that occurs during DNA transcription andreplication. It catalyzes the transient breaking and rejoining oftwo strands of duplex DNA which allows the strands to pass throughone another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. Thegene encoding this form, beta, is localized to chromosome 3 and thealpha form is localized to chromosome 17. The gene encoding thisenzyme functions as the target for several anticancer agents and avariety of mutations in this gene have been associated with thedevelopment of drug resistance. Reduced activity of this enzyme mayalso play a role in ataxia-telangiectasia. Alternative splicing ofthis gene results in two transcript variants; however, the secondvariant has not yet been fully described.
Other Names:
DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B
Gene Name: TOP2B
Gene ID: 7155
Primary Accession: Q02880
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a DNA topoisomerase, an enzyme thatcontrols and alters the topologic states of DNA duringtranscription. This nuclear enzyme is involved in processes such aschromosome condensation, chromatid separation, and the relief oftorsional stress that occurs during DNA transcription andreplication. It catalyzes the transient breaking and rejoining oftwo strands of duplex DNA which allows the strands to pass throughone another, thus altering the topology of DNA. Two forms of thisenzyme exist as likely products of a gene duplication event. Thegene encoding this form, beta, is localized to chromosome 3 and thealpha form is localized to chromosome 17. The gene encoding thisenzyme functions as the target for several anticancer agents and avariety of mutations in this gene have been associated with thedevelopment of drug resistance. Reduced activity of this enzyme mayalso play a role in ataxia-telangiectasia. Alternative splicing ofthis gene results in two transcript variants; however, the secondvariant has not yet been fully described.
Other Names:
DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B
Gene Name: TOP2B
Gene ID: 7155
Primary Accession: Q02880
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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