TORC1 (clone ), anti-human, mouse, rat, monkey
€388.00
In stock
SKU
MB0169
Background:
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.
Alternative Name:
KIAA0616, CREB regulated transcription coactivator 1, CREB-regulated transcription coactivator 1, CRTC1, CRTC1, FLJ14027, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated 1, Mucoepidermoid carcinoma translocated protein 1, TORC-1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, Transducer of regulated cAMP response element-binding protein (CREB) 1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1, MECT1, TORC1, TORC-1, WAMTP1.
Application Dilution: WB: 1:1000~2000
Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins
Immunogen:
Recombinant full length Human TORC1.
MW: Predicted band size: 78KDa, Observed band size: 78KDa
Swis Prot.: Q6UUV9
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgM. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 ´Ser-133´ phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.
Alternative Name:
KIAA0616, CREB regulated transcription coactivator 1, CREB-regulated transcription coactivator 1, CRTC1, CRTC1, FLJ14027, KIAA0616, MECT 1, Mucoepidermoid carcinoma translocated 1, Mucoepidermoid carcinoma translocated protein 1, TORC-1, TORC1, Transducer of CREB protein 1, Transducer of regulated cAMP response element binding protein 1, Transducer of regulated cAMP response element-binding protein (CREB) 1, Transducer of regulated cAMP response element-binding protein 1, WAMTP1, MECT1, TORC1, TORC-1, WAMTP1.
Application Dilution: WB: 1:1000~2000
Specificity: This antibody detects endogenous levels of TORC1 and does not cross-react with related proteins
Immunogen:
Recombinant full length Human TORC1.
MW: Predicted band size: 78KDa, Observed band size: 78KDa
Swis Prot.: Q6UUV9
Purification & Purity:
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Mouse IgM. Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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