TOX3/TNRC9 [clone TOX3/1123], anti-human

Description: It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.Localization: cytoplasm, nucleusDilution: 50-200Positive Control: SH-SY5Y, MDA-MB-435 cells. Brain or breast or gastric CarcinomaHIER: EDTA pH8.0Status: RUO