TP53 monoclonal (N-term), anti-human

Background:
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Other Names:
Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53, P53

Target/Specificity:
Purified His-tagged TP53 protein was used to produced this monoclonal antibody.

Antigen Type: Recombinant Protein

Gene Name: TP53
Gene ID: 7157
Primary Accession: P04637
NCBI Accession: NP_000537.3;NP_001119584.1;NP_001119585.1;NP_001119586.1;NP_001119587.1;NP_001119588.1;NP_001119589.1;NP_001119590.1;NP_001263624.1;NP_001263625.1;NP_001263626.1;NP_001263627.1;NP_001263628.1;NP_00126
Format: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.