Histone H2A.X (Phospho Ser139) polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP63456
Catalog Number: AC-AP72892
Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IF
Datasheet
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Size: 100 µl
Host: Rabbit
Applications: WB, IHC-P, IF
Datasheet
Request Information
Background:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
H2AFX; H2AX; Histone H2A.x; H2a/x
Antigen Type: synthetic peptide
Antigen Type: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation.
Other Names:
H2AFX; H2AX; Histone H2A.x; H2a/x
Antigen Type: synthetic peptide
Antigen Type: H2AX (HGNC:4739)
Gene ID: 3014
Primary Accession: P16104
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