TPIT1/TBX19 [clone CL6251], anti-human

Description: T-box transcription factor (TBX19 or TPIT) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX19 is the human ortholog of mouse Tbx19/Tpit gene. Studies in mouse show that Tpit protein is present only in the two pituitary pro-opiomelanocortin (POMC)-expressing lineages, the corticotrophs and melanotrophs. Mutations in the human ortholog were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage.Localization: nucleusDilution: 50-200Positive Control: pituitary gland tissueHIER: citrate pH6.0 or EDTA pH8.0Status: RUO