TPMT polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6297
Background:
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency).TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
Alternative Name:
HGNC:12014, S adenosyl L methionine thiopurine S methyltransferase, Thiopurine methyltransferase, Thiopurine S methyltransferase, Thiopurine S-methyltransferase, TPMT, TPMT,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: TPMT polyclonal antibody detects endogenous levels of TPMT protein.
Immunogen:
Recombinant full length Human TPMT.
MW: ~ 28 kDa
Swis Prot.: P51580
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency).TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
Alternative Name:
HGNC:12014, S adenosyl L methionine thiopurine S methyltransferase, Thiopurine methyltransferase, Thiopurine S methyltransferase, Thiopurine S-methyltransferase, TPMT, TPMT,
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: TPMT polyclonal antibody detects endogenous levels of TPMT protein.
Immunogen:
Recombinant full length Human TPMT.
MW: ~ 28 kDa
Swis Prot.: P51580
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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