TPO antibody (clone 2A11), anti-human
€435.00
In stock
SKU
AC-AT4322a
Catalog Number: AC-AT4322a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB, E
Request Information AC-AT4322a">Request Information
Background:
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined.
Other Names:
Thyroid peroxidase, TPO, TPO
Antigen Type:
Recombinant Protein
Gene Name: TPO (HGNC:12015)
Gene ID: 7173
NCBI Accession: NP_000538.3;NP_001193673.1;NP_001193674.1;NP_783650.1;NP_783652.1;NP_783653.1
Primary Accession: P07202
Other Accession: NM_000547
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Additional splice variants have been described but their biological natures have not been determined.
Other Names:
Thyroid peroxidase, TPO, TPO
Antigen Type:
Recombinant Protein
Gene Name: TPO (HGNC:12015)
Gene ID: 7173
NCBI Accession: NP_000538.3;NP_001193673.1;NP_001193674.1;NP_783650.1;NP_783652.1;NP_783653.1
Primary Accession: P07202
Other Accession: NM_000547
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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