TRAF1 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13946a
Background:
The protein encoded by this gene is a member of the TNFreceptor (TNFR) associated factor (TRAF) protein family. TRAFproteins associate with, and mediate the signal transduction fromvarious receptors of the TNFR superfamily. This protein and TRAF2form a heterodimeric complex, which is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. Theprotein complex formed by this protein and TRAF2 also interactswith inhibitor-of-apoptosis proteins (IAPs), and thus mediates theanti-apoptotic signals from TNF receptors. The expression of thisprotein can be induced by Epstein-Barr virus (EBV). EBV infectionmembrane protein 1 (LMP1) is found to interact with this and otherTRAF proteins; this interaction is thought to link LMP1-mediated Blymphocyte transformation to the signal transduction from TNFRfamily receptors. Three transcript variants encoding two differentisoforms have been found for this gene.
Other Names:
TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13946a was selected from the N-term region of TRAF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TRAF1
Gene ID: 7185
Primary Accession: Q13077
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a member of the TNFreceptor (TNFR) associated factor (TRAF) protein family. TRAFproteins associate with, and mediate the signal transduction fromvarious receptors of the TNFR superfamily. This protein and TRAF2form a heterodimeric complex, which is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. Theprotein complex formed by this protein and TRAF2 also interactswith inhibitor-of-apoptosis proteins (IAPs), and thus mediates theanti-apoptotic signals from TNF receptors. The expression of thisprotein can be induced by Epstein-Barr virus (EBV). EBV infectionmembrane protein 1 (LMP1) is found to interact with this and otherTRAF proteins; this interaction is thought to link LMP1-mediated Blymphocyte transformation to the signal transduction from TNFRfamily receptors. Three transcript variants encoding two differentisoforms have been found for this gene.
Other Names:
TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13946a was selected from the N-term region of TRAF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TRAF1
Gene ID: 7185
Primary Accession: Q13077
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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