TRAIL Antibody (Center N109) Blocking peptide
€363.00
In stock
SKU
AC-BP12271c
Background:
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thisprotein preferentially induces apoptosis in transformed and tumorcells, but does not appear to kill normal cells although it isexpressed at a significant level in most normal tissues. Thisprotein binds to several members of TNF receptor superfamilyincluding TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activityof this protein may be modulated by binding to the decoy receptorsTNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannotinduce apoptosis. The binding of this protein to its receptors hasbeen shown to trigger the activation of MAPK8/JNK, caspase 8, andcaspase 3. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL
Gene Name: TNFSF10
Gene ID: 8743
Primary Accession: P50591
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thisprotein preferentially induces apoptosis in transformed and tumorcells, but does not appear to kill normal cells although it isexpressed at a significant level in most normal tissues. Thisprotein binds to several members of TNF receptor superfamilyincluding TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3,TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activityof this protein may be modulated by binding to the decoy receptorsTNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannotinduce apoptosis. The binding of this protein to its receptors hasbeen shown to trigger the activation of MAPK8/JNK, caspase 8, andcaspase 3. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Other Names:
Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL
Gene Name: TNFSF10
Gene ID: 8743
Primary Accession: P50591
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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