Transglutaminase (TGM2) Blocking Peptide (C-term)

Background:
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally,the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

Other Names:
Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, TG(C), TGC, TGase C, Transglutaminase H, TGase H, Transglutaminase-2, TGase-2, TGM2

Target/Specificity:
The synthetic peptide sequence is selected from aa 592~606 of HUMAN TGM2

Gene Name: TGM2 {ECO:0000303|PubMed:17939176, ECO:0000312|HGNC:HGNC:11778}

Gene ID: 7052
Primary Accession: P21980
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.