TRIAD3 (UBCE7IP1) Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP2106a
Background:
UBCE7IP1 might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. It inhibits TNF and IL-1 mediated activation of NF-kappa-B, and promotes TNF and RIP mediated apoptosis. Evidence exists to suggest an interaction with UBE2L3 and RIPK1. Expression is ubiquitous, with the highest levels in testis and peripheral blood leukocytes. Structurally, the protein contains a putative 1 IBR-type zinc finger and 2 RING-type zinc fingers.
Other Names:
E3 ubiquitin-protein ligase RNF216, 632-, RING finger protein 216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B, RNF216, TRIAD3, UBCE7IP1, ZIN
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2106a was selected from the N-term region of human UBCE7IP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RNF216
Gene ID: 54476
Primary Accession: Q9NWF9
Other Accession: NP_996994
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
UBCE7IP1 might act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. It inhibits TNF and IL-1 mediated activation of NF-kappa-B, and promotes TNF and RIP mediated apoptosis. Evidence exists to suggest an interaction with UBE2L3 and RIPK1. Expression is ubiquitous, with the highest levels in testis and peripheral blood leukocytes. Structurally, the protein contains a putative 1 IBR-type zinc finger and 2 RING-type zinc fingers.
Other Names:
E3 ubiquitin-protein ligase RNF216, 632-, RING finger protein 216, Triad domain-containing protein 3, Ubiquitin-conjugating enzyme 7-interacting protein 1, Zinc finger protein inhibiting NF-kappa-B, RNF216, TRIAD3, UBCE7IP1, ZIN
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP2106a was selected from the N-term region of human UBCE7IP1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: RNF216
Gene ID: 54476
Primary Accession: Q9NWF9
Other Accession: NP_996994
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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