TRIB2 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP8930b
Background:
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Other Names:
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8930b was selected from the C-term region of human TRIB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TRIB2 (HGNC:30809)
Gene ID: 28951
Primary Accession: Q92519
Other Accession: NP_067675
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Other Names:
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8930b was selected from the C-term region of human TRIB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TRIB2 (HGNC:30809)
Gene ID: 28951
Primary Accession: Q92519
Other Accession: NP_067675
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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