TRIB2 antibody (clone 1B1), anti-human
€435.00
In stock
SKU
AC-AT4338a
Catalog Number: AC-AT4338a
Size: 100 µg
Isotype: mouse IgG2b Lambda
Applications: WB, IHC, E
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Size: 100 µg
Isotype: mouse IgG2b Lambda
Applications: WB, IHC, E
Request Information AC-AT4338a">Request Information
Background:
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Other Names:
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Antigen Type:
Recombinant Protein
Gene Name: TRIB2 (HGNC:30809)
Gene ID: 28951
NCBI Accession: NP_067675.1
Primary Accession: Q92519
Other Accession: NM_021643
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene.
Other Names:
Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)
Antigen Type:
Recombinant Protein
Gene Name: TRIB2 (HGNC:30809)
Gene ID: 28951
NCBI Accession: NP_067675.1
Primary Accession: Q92519
Other Accession: NM_021643
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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