Trim5 alpha (clone 3B11H2), anti-human
€539.00
In stock
SKU
252615
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
TRIM5-alpha (Tripartite motif-containing protein 5) is a protein that is found in the cells of many mammals and fends off various retrovirus infections. It protects monkeys from infection with HIV-1 and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Alternate Names: Tripartite motif-containing protein 5, RING finger protein 88, RNF88, TRIM5
Application Notes: WB: 1:500-1:2000, IHC: 1:200-1:1000
Accession No.: Q9C035
Antigen: Purified recombinant fragment of human trim5 alpha expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
TRIM5-alpha (Tripartite motif-containing protein 5) is a protein that is found in the cells of many mammals and fends off various retrovirus infections. It protects monkeys from infection with HIV-1 and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Alternate Names: Tripartite motif-containing protein 5, RING finger protein 88, RNF88, TRIM5
Application Notes: WB: 1:500-1:2000, IHC: 1:200-1:1000
Accession No.: Q9C035
Antigen: Purified recombinant fragment of human trim5 alpha expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
| Is Featured? | No |
|---|
Write Your Own Review