TRIP12 polyclonal, anti-human
€388.00
In stock
SKU
BS71385
Background:
TRIP12 (thyroid hormone receptor interactor 12) is a 1,992 amino acid E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway. TRIP12 also modulates the NEDD8 pathway, a series of steps implicated in signal transduction and cell cycle progression, where it influences APPBP1 degradation by catalyzing its ubiquitination. A member of the UPL family and K-HECT subfamily, TRIP 12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site. Subject to post-translational phosphorylation upon DNA damage, TRIP12 expression is highest in testis and skeletal muscle, and has also been found in heart, spleen, thymus, ovary, placenta, kidney, prostate and peripheral blood leukocytes at lower levels.
Alternative Name:
E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf, Thyroid receptor-interacting protein 12, TR-interacting protein 12, TRIP-12, TRIP12, KIAA0045, ULF
Application Dilution: WB: 1:500 - 1:1000
Specificity: TRIP12 polyclonal antibody detects endogenous levels of TRIP12 protein.
Immunogen:
Recombinant protein of human TRIP12.
MW: ~ 220 kDa
Swis Prot.: Q14669
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
TRIP12 (thyroid hormone receptor interactor 12) is a 1,992 amino acid E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway. TRIP12 also modulates the NEDD8 pathway, a series of steps implicated in signal transduction and cell cycle progression, where it influences APPBP1 degradation by catalyzing its ubiquitination. A member of the UPL family and K-HECT subfamily, TRIP 12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site. Subject to post-translational phosphorylation upon DNA damage, TRIP12 expression is highest in testis and skeletal muscle, and has also been found in heart, spleen, thymus, ovary, placenta, kidney, prostate and peripheral blood leukocytes at lower levels.
Alternative Name:
E3 ubiquitin-protein ligase TRIP12, E3 ubiquitin-protein ligase for Arf, Thyroid receptor-interacting protein 12, TR-interacting protein 12, TRIP-12, TRIP12, KIAA0045, ULF
Application Dilution: WB: 1:500 - 1:1000
Specificity: TRIP12 polyclonal antibody detects endogenous levels of TRIP12 protein.
Immunogen:
Recombinant protein of human TRIP12.
MW: ~ 220 kDa
Swis Prot.: Q14669
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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