TrkA (clone 6B2), anti-human
€478.00
In stock
SKU
252878
Protein Family: Enzymes, Protein Kinases, Receptors and Channels
Pathway and Disease: Cancers, Cell Growth and Death, Nervous and Sensory Systems, Signal Transduction
Description:
TrkA is a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA exists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.
Alternate Names: High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, p140-TrkA, Trk-A, NTRK1, TRK
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000
Accession No.: P04629
Antigen: Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Cell Growth and Death, Nervous and Sensory Systems, Signal Transduction
Description:
TrkA is a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of TrkA in neural cell lines and embryonic dorsal root ganglia. TrkA is a receptor of high-affinity for NGF, neurotrophin-3 and neurotrophin 4/5 but not BDNF. TrkA exists in a dynamic equilibrim between monomeric (low affinity) and dimeric (high affinity) structures. TrkA has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Defects in TrkA are a cause of congenital insentivity to pain with anhidrosis. Chromosomal aberrations involving TrkA are a cause of thyroid papillary carcinoma.
Alternate Names: High affinity nerve growth factor receptor, Neurotrophic tyrosine kinase receptor type 1, TRK1-transforming tyrosine kinase protein, p140-TrkA, Trk-A, NTRK1, TRK
Application Notes: WB: 1:500-1:2000; IF: 1:200-1:1000
Accession No.: P04629
Antigen: Purified recombinant extracellular fragment of human TrkA(aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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