TrkB human recombinant protein
€0.00
In stock
SKU
ATGP4152
Catalog Number: ATGP4152
Size(s): 10μg, 20μg, 50μg, 100μg, 250μg, 500μg, 1 mg
Expression system: HEK293
Reactivity: human
Applications: SDS-PAGE
Datasheet
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Size(s): 10μg, 20μg, 50μg, 100μg, 250μg, 500μg, 1 mg
Expression system: HEK293
Reactivity: human
Applications: SDS-PAGE
Datasheet
Request Information
Background:
TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names:
GP145-TrkB, trk-B, TRKB, NTRK2, OBHD, BDNF/NT-3 growth factors receptor isoform c, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B
Domain: 32-430aa
Sequence:
CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH
UniProt No.: Q16620
NCBI Accession No.: NP_001018074.1
Molecular Weight: 70.3kDa (632aa)
Concentration: 1mg/ml (determined by absorbance at 280nm)
Formulation: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Purity: > 90% by SDS-PAGE
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Endotoxin: hIgG-Tag
Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
TrkB/NTRK2, also known as BDNF/NT-3 growth factors receptor, is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Trk family are four members ; TrkA, TrkB, TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities and TrkB has the highest affinity for BDNF. It plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. Mutations in TrkB have been associated with obesity and mood disorders. Recombinant human TrkB/NTRK2, fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Alternative Names:
GP145-TrkB, trk-B, TRKB, NTRK2, OBHD, BDNF/NT-3 growth factors receptor isoform c, BDNF/NT-3 growth factors receptor, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B
Domain: 32-430aa
Sequence:
CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH
UniProt No.: Q16620
NCBI Accession No.: NP_001018074.1
Molecular Weight: 70.3kDa (632aa)
Concentration: 1mg/ml (determined by absorbance at 280nm)
Formulation: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Purity: > 90% by SDS-PAGE
Endotoxin: < 1 EU per 1ug of protein (determined by LAL method)
Endotoxin: hIgG-Tag
Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
| Is Featured? | No |
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