TRMT11 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60656
Background:
TRM11 (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) is a 463 amino acid protein that belongs to the methyltransferase superfamily. TRM11 is believed to be the catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. The gene encoding TRM11 maps to a region on chromosome 6 that is shared by seven other genes, which have been linked to diffuse panbronchiolitis. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Alternative Name:
tRNA (guanine(10)-N2)-methyltransferase homolog, tRNA guanosine-2'-O-methyltransferase TRM11 homolog, TRMT11, C6orf75, MDS024, TRM11
Application Dilution: WB: 1:500~1:1000
Specificity: TRMT11 polyclonal antibody detects endogenous levels of TRMT11 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human TRMT11
MW: ~ 53 kDa
Swis Prot.: Q7Z4G4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
TRM11 (tRNA guanosine-2'-O-methyltransferase TRM11 homolog) is a 463 amino acid protein that belongs to the methyltransferase superfamily. TRM11 is believed to be the catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. The gene encoding TRM11 maps to a region on chromosome 6 that is shared by seven other genes, which have been linked to diffuse panbronchiolitis. Chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.
Alternative Name:
tRNA (guanine(10)-N2)-methyltransferase homolog, tRNA guanosine-2'-O-methyltransferase TRM11 homolog, TRMT11, C6orf75, MDS024, TRM11
Application Dilution: WB: 1:500~1:1000
Specificity: TRMT11 polyclonal antibody detects endogenous levels of TRMT11 protein.
Immunogen:
A synthetic peptide corresponding to residues in Human TRMT11
MW: ~ 53 kDa
Swis Prot.: Q7Z4G4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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