Trypsin (clone 7C8), anti-human, bovine
€595.00
In stock
SKU
250298
Protein Family: Enzymes, Peptidases
Pathway and Disease: Signaling Molecules and Interaction
Description:
Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis. This antibody is specific for human trypsin, trypsinogen and trypsin in complex with alpha-1-antitrypsin and reacts weakly with bovine trypsin.
Alternate Names: Trypsin I, Cationic trypsinogen, Serine protease 1, Beta-trypsin
Application Notes: Product Cat. No. 250298 reacts with human trypsin coated directly in a microplate. Product Cat. No. 250298 can be used as both capture and detection antibody in sandwich ELISA. Product Cat. No. 250298 recognizes human trypsin in Western blot under reducing conditions. Epitope bound by 250298 differs from epitope recognized by Cat. No. 250299. E: 1:8,000; WB: 1:500
Accession No.: P07477
Antigen: Trypsin purified from human pancreatic tissue
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis. This antibody is specific for human trypsin, trypsinogen and trypsin in complex with alpha-1-antitrypsin and reacts weakly with bovine trypsin.
Alternate Names: Trypsin I, Cationic trypsinogen, Serine protease 1, Beta-trypsin
Application Notes: Product Cat. No. 250298 reacts with human trypsin coated directly in a microplate. Product Cat. No. 250298 can be used as both capture and detection antibody in sandwich ELISA. Product Cat. No. 250298 recognizes human trypsin in Western blot under reducing conditions. Epitope bound by 250298 differs from epitope recognized by Cat. No. 250299. E: 1:8,000; WB: 1:500
Accession No.: P07477
Antigen: Trypsin purified from human pancreatic tissue
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.
Storage:
Store at 4°C. Product is guaranteed 6 months from the date of shipment.
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