TSC22D3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8433
Background:
Glucocorticoid-induced leucine zipper (GILZ) is a leucine zipper protein ex-pressed in normal lymphocytes from thymus, spleen and lymph nodes. It is absent in nonlymphoid tissues including brain, liver and kidney. GILZ mediates the immunosuppressive effects of glucocorticoid hormones; its expression is induced in T cells by dexamethasone. GILZ protects T cells from an anti-CD3 antibody-induced apoptosis by inhibiting Fas and Fas ligand expression. It interferes with Egr-2, Egr-3, NFAT/AP-1-inducible transcription factors and AP-1. The interaction of GILZ with c-Fos and c-Jun inhibits the binding of active AP-1 to its DNA consensus site in vitro. GILZ also binds NFkB subunits and inhibits the NFkB nuclear translocation. It inhibits T cell receptor-induced interleukin-2/interleukin-2 receptor expression. The binding of GILZ to Raf-1 prevents Raf-MEK-ERK activation in the MAPK pathway. GILZ is expressed by normal macrophages in nonlymphoid tissues and by tumor-infiltrating macrophages in Burkitt lymphomas. The gene encoding human GILZ maps to chromosome Xq22.3.
Alternative Name:
TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, GILZ
Application Dilution: WB: 1:500 - 1:2000, IHC, 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:100
Specificity: TSC22D3 polyclonal antibody detects endogenous levels of TSC22D3 protein.
Immunogen:
Recombinant full length Human TSC22D3.
MW: ~ 15 kDa
Swis Prot.: Q99576
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Glucocorticoid-induced leucine zipper (GILZ) is a leucine zipper protein ex-pressed in normal lymphocytes from thymus, spleen and lymph nodes. It is absent in nonlymphoid tissues including brain, liver and kidney. GILZ mediates the immunosuppressive effects of glucocorticoid hormones; its expression is induced in T cells by dexamethasone. GILZ protects T cells from an anti-CD3 antibody-induced apoptosis by inhibiting Fas and Fas ligand expression. It interferes with Egr-2, Egr-3, NFAT/AP-1-inducible transcription factors and AP-1. The interaction of GILZ with c-Fos and c-Jun inhibits the binding of active AP-1 to its DNA consensus site in vitro. GILZ also binds NFkB subunits and inhibits the NFkB nuclear translocation. It inhibits T cell receptor-induced interleukin-2/interleukin-2 receptor expression. The binding of GILZ to Raf-1 prevents Raf-MEK-ERK activation in the MAPK pathway. GILZ is expressed by normal macrophages in nonlymphoid tissues and by tumor-infiltrating macrophages in Burkitt lymphomas. The gene encoding human GILZ maps to chromosome Xq22.3.
Alternative Name:
TSC22 domain family protein 3, DSIP-immunoreactive peptide, Protein DIP, hDIP, Delta sleep-inducing peptide immunoreactor, Glucocorticoid-induced leucine zipper protein, GILZ, TSC-22-like protein, TSC-22-related protein, TSC-22R, TSC22D3, DSIPI, GILZ
Application Dilution: WB: 1:500 - 1:2000, IHC, 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:50 - 1:100
Specificity: TSC22D3 polyclonal antibody detects endogenous levels of TSC22D3 protein.
Immunogen:
Recombinant full length Human TSC22D3.
MW: ~ 15 kDa
Swis Prot.: Q99576
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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