TSG101 antibody (clone 5B7), anti-human
€435.00
In stock
SKU
AC-AT4378a
Catalog Number: AC-AT4378a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
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Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IHC, IF, E
Request Information AC-AT4378a">Request Information
Background:
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Other Names:
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Antigen Type:
Recombinant Protein
Gene Name: TSG101
Gene ID: 7251
NCBI Accession: NP_006283.1
Primary Accession: Q99816
Other Accession: NM_006292
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression.
Other Names:
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Antigen Type:
Recombinant Protein
Gene Name: TSG101
Gene ID: 7251
NCBI Accession: NP_006283.1
Primary Accession: Q99816
Other Accession: NM_006292
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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