TSG101 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6042
Background:
The transformation of a normal cell to one that is malignant can result from mutations in genes that encode proteins with key regulatory functions. Examples include the retinoblastoma gene product (Rb p110), p53, VHL and APC. Using a novel cloning strategy that allows the isolation of previously uncharacterized genes encoding selectable recessive phenotypes, an additional tumor suppressor gene has been identified. This gene, termed tsg 101 for tumor susceptibility gene 101, encodes a stathmin binding domain protein. When expression of this growth inhibitory gene is blocked in NIH/3T3 cells using antisense mRNA, the cells exhibit a transformed phenotype and are tumorigenic in SL6 mice.
Alternative Name:
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: TSG101 polyclonal antibody detects endogenous levels of TSG101 protein.
Immunogen:
Recombinant full length Human TSG101.
MW: ~ 44 kDa
Swis Prot.: Q99816
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The transformation of a normal cell to one that is malignant can result from mutations in genes that encode proteins with key regulatory functions. Examples include the retinoblastoma gene product (Rb p110), p53, VHL and APC. Using a novel cloning strategy that allows the isolation of previously uncharacterized genes encoding selectable recessive phenotypes, an additional tumor suppressor gene has been identified. This gene, termed tsg 101 for tumor susceptibility gene 101, encodes a stathmin binding domain protein. When expression of this growth inhibitory gene is blocked in NIH/3T3 cells using antisense mRNA, the cells exhibit a transformed phenotype and are tumorigenic in SL6 mice.
Alternative Name:
Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, TSG101
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: TSG101 polyclonal antibody detects endogenous levels of TSG101 protein.
Immunogen:
Recombinant full length Human TSG101.
MW: ~ 44 kDa
Swis Prot.: Q99816
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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