TSLP polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS8051
Background:
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The gene encoding murine TSLP maps to chromosome 18 and its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex. TSLP first binds with low affinity to a TSLP-specific chain designated TSLPR, and then forms a high affinity complex with the IL-7Rα subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7RRα on monocytes and dendritic cells.
Alternative Name:
Thymic stromal lymphopoietin, TSLP
Application Dilution: WB: 1:1000 - 1:3000
Specificity: TSLP polyclonal antibody detects endogenous levels of TSLP protein.
Immunogen:
Recombinant full length Human TSLP.
MW: ~ 18 kDa
Swis Prot.: Q969D9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The gene encoding murine TSLP maps to chromosome 18 and its human homologue is expressed in several tissues, including heart, liver and prostate. TSLP mediates its function by binding to a receptor complex. TSLP first binds with low affinity to a TSLP-specific chain designated TSLPR, and then forms a high affinity complex with the IL-7Rα subunit, which explains the overlapping biological properties between TSLP and IL-7. Both TSLP and IL-7 induce phosphorylation of the transcription factor Stat5, but unlike IL-7, TSLP-mediated signaling does not activate the JAKs. TSLP prevents apoptosis and stimulates the proliferation of myeloid cells, which is supported by the coexpression of TSLPR and IL-7RRα on monocytes and dendritic cells.
Alternative Name:
Thymic stromal lymphopoietin, TSLP
Application Dilution: WB: 1:1000 - 1:3000
Specificity: TSLP polyclonal antibody detects endogenous levels of TSLP protein.
Immunogen:
Recombinant full length Human TSLP.
MW: ~ 18 kDa
Swis Prot.: Q969D9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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