TTR antibody (clone 4D8), anti-human
€435.00
In stock
SKU
AC-AT4395a
Catalog Number: AC-AT4395a
Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 Kappa
Applications: WB, E
Request Information AC-AT4395a">Request Information
Background:
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Other Names:
Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB
Antigen Type:
Recombinant Protein
Gene Name: TTR
Gene ID: 7276
NCBI Accession: NP_000362.1
Primary Accession: P02766
Other Accession: BC020791
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Other Names:
Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB
Antigen Type:
Recombinant Protein
Gene Name: TTR
Gene ID: 7276
NCBI Accession: NP_000362.1
Primary Accession: P02766
Other Accession: BC020791
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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